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A 47-year-old man with idiopathic dilated cardiomyopathy and premature ventricular depolarizations (PVDs) was stable on propranolol and digoxin (4 to 5 PVDs/min). Propranolol was my last hope and thankfully it works beautifully. The effect of pindolol on the AV node is less than propranolol. Propranolol can help prevent migraine headaches; relieve serious tremors (uncontrollable shaking); and help certain problems related to the  thyroid gland and adrenal gland. AUC and Cmax differences were <20% between isradipine given singly and in combination with propranolol, and between propranolol given singly and in combination with isradipine. However, if it is within 4 hours of your next dose (8 hours when using atenolol, betaxolol, bisoprolol, carteolol, labetalol, nadolol, penbutolol, sotalol, or extended-release [long-acting] metoprolol, oxprenolol, or propranolol), skip the missed dose and go back to your regular dosing schedule.

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