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In many cases, the relationship to Cardizem has not been established. Cardizem prolongs AV node refractory periods without significantly prolonging sinus node recovery time, except in patients with sick sinus syndrome. Controlled and uncontrolled domestic studies suggest that concomitant use of Cardizem and beta-blockers is usually well tolerated. Cardizem, Cardizem CD, and Cardizem LA (an extended-release, once-a-day tablet form of diltiazem) are used to control chronic stable angina (caused by exertion). In vitro binding studies show Cardizem is 70% to 80% bound to plasma proteins. Spontaneous and ergonovine-induced coronary artery spasm are inhibited by Cardizem.

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